Clinical significance of apolipoprotein A5
نویسندگان
چکیده
منابع مشابه
Evaluation of Apolipoprotein A5 Polymorphism in Coronary- Heart Disease Patients
Background and Objectives: Apolipoprotein A5 (APOA5) gene is important in determining plasma triglyceride levels, a major cardiovascular disease risk factor. Mutation in this gene affected plasma triglyceride level. We looked for possible associations of the APOA5 gene polymorphism S19W with coronary heart disease (CHD) in a sample of Iranian population. Materials and Methods: A total of 7...
متن کاملApolipoprotein A5 and hypertriglyceridemia.
Hypertriglyceridemia is associated with increased risk of coronary heart disease (CHD) (1–5), and it is an integral component of the overlapping syndromes of familial combined hyperlipidemia, insulin resistance syndrome, atherogenic lipoprotein profile, and hyperapobetalipoproteinemia (6 ). More than one mechanism may be involved in the increased risk of CHD associated with increased serum trig...
متن کاملApolipoprotein A5 in health and disease.
High plasma levels of triglycerides (TG) are an independent risk factor in the development of cardiovascular disease, with about 50 % of the final levels being determined genetically. Apolipoprotein A5 (APOA5) is the last discovered member of the apolipoprotein APOA1/C3/A4 gene cluster, found by comparative sequencing analysis. The importance of APOA5 gene for determination of plasma triglyceri...
متن کاملTwo independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels.
The recently identified apolipoprotein A5 gene (APOA5) has been shown to play an important role in determining plasma triglyceride concentrations in humans and mice. We previously identified an APOA5 haplotype (designated APOA5*2) that is present in approximately 16% of Caucasians and is associated with increased plasma triglyceride concentrations. In this report we describe another APOA5 haplo...
متن کاملApolipoprotein A5 and hypertriglyceridemia in Prague hypertriglyceridemic rats.
High plasma triglyceride (TG) level is a major independent risk factor of coronary heart disease. A newly identified Apolipoprotein A5 (Apoa5) gene has been shown to play an important role in determining plasma TG concentrations in humans and mice. Prague hereditary hypertriglyceridemic (HTG) rats are a useful model of human hypertriglyceridemia and other symptoms of metabolic syndrome. Thus, t...
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ژورنال
عنوان ژورنال: Current Opinion in Lipidology
سال: 2008
ISSN: 0957-9672
DOI: 10.1097/mol.0b013e328304b681